Francisella tularensis is a cause of potentially severe zoonotic disease in humans; sometimes referred to as rabbit fever or deer-fly fever.
Tests generally appear in the order most useful for common clinical situations
| Test name: Francisella tularensis Antibodies, IgG and IgM |
| ARUP #: 2005350 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: Diagnose F. tularensis as agent of infection |
| Limitations: Cross-reactions with Brucella or Yersinia antibodies may occur; results should be interpreted with caution and correlated with clinical information; the best evidence for current infection is significant change on two appropriately timed specimens |
| Test name: Organism Identification by 16S rDNA Sequencing |
| ARUP #: 0060720 |
| Methodology: 16S rDNA Sequencing |
| Comments: If suspected, notify laboratory to rule out F. tularensis |
| Test name: Aerobic Organism Identification |
| ARUP #: 0060115 |
| Methodology: Identification methods including Biochemical, MALDI TOF and/or 16S rDNA sequencing. |
| Comments: If suspected, notify laboratory to rule out F. tularensis For suspected agents of bioterrorism, notify state department of health and refer isolates to state laboratory for identification Susceptibilities on agents of bioterrorism are not performed at ARUP |
| Test name: Rickettsia typhi (Typhus Fever) Antibody, IgM by IFA |
| ARUP #: 0050383 |
| Methodology: Semi-Quantitative Indirect Fluorescent Antibody |
| Comments: |
| Test name: Rickettsia rickettsii (Rocky Mountain Spotted Fever) Antibody, IgG |
| ARUP #: 0050369 |
| Methodology: Semi-Quantitative Indirect Fluorescent Antibody |
| Comments: |
| Test name: Brucella Antibody (Total) by Agglutination |
| ARUP #: 0050135 |
| Methodology: Semi-Quantitative Bacterial Agglutination |
| Comments: Cross-reactions may occur between Brucella and F.tularensis antigens and antisera; therefore, parallel tests should be run with these antigens; a fourfold rise in titer is considered diagnostic |
| Test name: Francisella tularensis Antibody, IgG |
| ARUP #: 2005353 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Comments: Cross-reactions with Brucella or Yersinia antibodies may occur; results should be interpreted with caution and correlated with clinical information; the best evidence for current infection is significant change on two appropriately timed specimens |
| Test name: Francisella tularensis Antibody, IgM |
| ARUP #: 2005354 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Comments: Cross-reactions with Brucella or Yersinia antibodies may occur; results should be interpreted with caution and correlated with clinical information; the best evidence for current infection is significant change on two appropriately timed specimens |