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Tetanus is a central nervous system disease caused by neurotoxin produced by Clostridium tetani.
Tests generally appear in the order most useful for common clinical situations
| Test name: CBC with Platelet Count & Automated Differential |
| ARUP #: 0040003 |
| Methodology: Automated Cell Count with Flow Cell Differential |
| Use: Evaluate for presence of leukocytosis |
| Test name: Meningoencephalitis Panel, CSF with Reflex to HSV Type 1 & Type 2 Glycoprotein G-Specific Ab, IgG |
| ARUP #: 2001765 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody |
| Use: Rule out other viral and bacterial etiologies of meningitis |
| Test name: Wound Culture (Includes Gram Stain 0060101) |
| ARUP #: 0060132 |
| Methodology: Standard reference procedures for bacterial stain, aerobic culture, and identification. Anaerobe Culture is performed on properly collected specimens (Anaerobe culture 0060143). |
| Use: Confirm C. tetani as organism of disease |
| Limitations: Negative culture does not rule out disease Isolates may be non-toxigenic |
| Test name: Tetanus Antibody, IgG |
| ARUP #: 0050535 |
| Methodology: Quantitative Multi-Analyte Fluorescent Detection |
| Use: Determine IgG antibodies in response to vaccination For tetanus antibody titer, order with diphtheria and tetanus antibodies, IgG Do not use to diagnose tetanus |
| Limitations: Requires comparison of samples taken prior to and 1 month after vaccination |
| Follow-up: If concentrations of IgG, IgM, and IgA are low, low-normal or even normal, and antibody deficiency still strongly suspected, determine IgG subclass and response to protein antigens such as diphtheria, tetanus toxoid, and H. influenzae, as well as to pure polysaccharide antigens such as unconjugated pneumococcal vaccine |
| Test name: Diphtheria, Tetanus, and H. Influenzae b Antibodies, IgG |
| ARUP #: 0050779 |
| Methodology: Quantitative Multi-Analyte Fluorescent Detection |
| Use: Determine IgG antibodies titers in response to vaccination Determine IgG antibody titers to tetanus and diphtheria toxoids and H. influenzae PRP simultaneously |
| Limitations: Requires comparison of samples taken prior to and 1 month after vaccination |
| Follow-up: If concentrations of IgG, IgM, and IgA are low, low-normal or even normal, and antibody deficiency still strongly suspected, determine IgG subclass and response to protein antigens such as diphtheria, tetanus toxoid, and H. influenzae as well as to pure polysaccharide antigens such as unconjugated pneumococcal vaccine |
| Test name: Strychnine |
| ARUP #: 0091574 |
| Methodology: Quantitative Gas Chromatography |
| Comments: |
| Test name: Strychnine, Quantitative, Urine |
| ARUP #: 0091075 |
| Methodology: Gas Chromatography |
| Comments: |
| Test name: Diphtheria & Tetanus Antibodies, IgG |
| ARUP #: 0050595 |
| Methodology: Quantitative Multi-Analyte Fluorescent Detection |
| Comments: For diphtheria antibody titer, order with diphtheria antibody, IgG to:
For tetanus antibody titer, order with tetanus antibody, IgG to:
If concentrations of IgG, IgM, and IgA are low, low-normal or even normal, and antibody deficiency still strongly suspected, determine IgG subclass and response to protein antigens such as diphtheria, tetanus toxoid, and Haemophilus influenzae as well as to pure polysaccharide antigens such as unconjugated pneumococcal vaccine |