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Somatostatinomas are rare, functional neuroendocrine tumors that produce excessive amounts of somatostatin. They occur in the pancreas and duodenum.
Tests generally appear in the order most useful for common clinical situations
| Test name: Somatostatin |
| ARUP #: 0098192 |
| Methodology: Quantitative Extraction/Radioimmunoassay |
| Use: Aid in diagnosis of somatostatinoma |
| Limitations: Modest somatostatin elevation may also occur in non-endocrine disorders |
| Follow-up: Serial fasting somatostatin levels should be obtained at 3 months and then at 6-month intervals after surgical resection |
| Test name: Synaptophysin by Immunohistochemistry |
| ARUP #: 2004139 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of neuroendocrine tissue Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Chromogranin A by Immunohistochemistry |
| ARUP #: 2003830 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of neuroendocrine tissue Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Pan Cytokeratin (AE1,3) by Immunohistochemistry |
| ARUP #: 2003433 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of somatostatinoma Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Ki-67 Tissue Assay, Paraffin |
| ARUP #: 0049270 |
| Methodology: Immunohistochemistry |
| Use: Aid in determining NET grade Determine mitotic rate in tissue Stained and resulted by ARUP |
| Test name: Somatostatin by Immunohistochemistry |
| ARUP #: 2004133 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of somatostatinoma Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Neuron Specific Enolase, Polyclonal (NSE P) by Immunohistochemistry |
| ARUP #: 2004052 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic identification of neural and neuroendocrine tissue Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Protein Gene Product (PGP) 9.5 by Immunohistochemistry |
| ARUP #: 2004091 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of somatostatinoma Stained and returned to client pathologist for interpretation; consultation available if needed |