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Pancreatic cancer, a common cancer in the U.S., has historically been associated with a high mortality rate. It has a low 5-year survival rate due to the typically late stage of cancer at time of diagnosis.
Tests generally appear in the order most useful for common clinical situations
| Test name: Hepatic Function Panel |
| ARUP #: 0020416 |
| Methodology: Quantitative Enzymatic/Quantitative Spectrophotometry |
| Use: Initial screening test for obstruction and jaundice Panel includes albumin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, bilirubin direct and total, protein total |
| Test name: Cancer Antigen-GI (CA 19-9) |
| ARUP #: 0080461 |
| Methodology: Quantitative Electrochemiluminescent Immunoassay |
| Use: Monitor pancreatic cancer 70-90% sensitivity and 90% specificity depending on cancer stage |
| Limitations: Cannot be interpreted as absolute evidence of the presence or absence of malignant disease May not be detectable in patients with Lewis-a negative blood group Results obtained with different methods cannot be used interchangeably |
| Test name: Cancer Antigen-GI (CA 19-9), Body Fluid |
| ARUP #: 0020746 |
| Methodology: Quantitative Electrochemiluminescent Immunoassay |
| Use: May aid diagnosis and monitoring of pancreatic cancer |
| Limitations: Cannot be interpreted as absolute evidence of the presence or absence of malignant disease Results obtained with different assay methods or kits cannot be used interchangeably |
| Test name: Pancreatobiliary FISH |
| ARUP #: 2002461 |
| Methodology: Fluorescence in situ Hybridization/Computer Assisted Analysis/Microscopy |
| Use: Detect aneuploidy for chromosomes 3, 7, and 17 Use in conjunction with current standard diagnostic procedures as an aid for initial diagnosis of pancreatic cancer |
| Limitations: Negative results indicate none of the numeric chromosomal abnormalities commonly associated with pancreatic carcinoma were identified in the specimen, but does not exclude the possibility of pancreatic carcinoma |
| Follow-up: If result is negative and high clinical suspicion exists, additional clinical studies should be considered |
| Test name: Amylase, Body Fluid |
| ARUP #: 0020506 |
| Methodology: Quantitative Enzymatic |
| Use: Assist with evaluating pancreatic cysts as benign or malignant |
| Test name: Muc-1 by Immunohistochemistry |
| ARUP #: 2004002 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: Carcinoembryonic Antigen, Fluid |
| ARUP #: 0020742 |
| Methodology: Quantitative Electrochemiluminescent Immunoassay |
| Use: Assist with evaluating pancreatic cysts as benign or malignant |
| Test name: Cytokeratin 8,18 Low Molecular Weight (CAM 5.2) by Immunohistochemistry |
| ARUP #: 2003493 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: Epithelial Membrane Antigen (EMA) by Immunohistochemistry |
| ARUP #: 2003872 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: p21 (Waf1/Cip 1) by Immunohistochemistry |
| ARUP #: 2004067 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: Protein Gene Product (PGP) 9.5 by Immunohistochemistry |
| ARUP #: 2004091 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: Synaptophysin by Immunohistochemistry |
| ARUP #: 2004139 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |
| Test name: Carcinoembryonic Antigen, Polyclonal (CEA P) by Immunohistochemistry |
| ARUP #: 2003827 |
| Methodology: Immunohistochemistry |
| Use: Aid histologic diagnosis of pancreatic cancer Stained and returned to client pathologist; consultation available if needed |