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JC virus (JCV) is a human neurotropic polyomavirus that is the etiologic agent of progressive multifocal leukoencephalopathy (PML).
Tests generally appear in the order most useful for common clinical situations
| Test name: Cell Count, CSF |
| ARUP #: 0095018 |
| Methodology: Cell Count/Differential |
| Use: Evaluate white blood cell count and differential in suspected infectious meningitis/encephalitis |
| Limitations: Findings not specific for JCV infections |
| Test name: Protein, Total, CSF |
| ARUP #: 0020514 |
| Methodology: Reflectance Spectrophotometry |
| Use: Evaluate protein level in suspected infectious meningitis/encephalitis |
| Limitations: Findings not specific for JCV infections |
| Test name: CSF Bacterial Culture (Includes Gram Stain 0060101) |
| ARUP #: 0060106 |
| Methodology: Standard reference procedures for bacterial stain, aerobic culture, and identification |
| Use: Confirm alternative etiology of infection |
| Test name: Meningoencephalitis Panel, CSF with Reflex to HSV Type 1 & Type 2 Glycoprotein G-Specific Ab, IgG |
| ARUP #: 2001765 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody |
| Use: Rule out other forms of encephalitis Panel includes California encephalitis, Eastern equine encephalitis, St. Louis equine encephalitis, Western equine encephalitis, West Nile virus, measles, mumps, varicella-zoster virus, HSV type 1 and 2, and lymphocytic choriomeningitis antibodies |
| Test name: Glucose, Plasma or Serum |
| ARUP #: 0020024 |
| Methodology: Quantitative Enzymatic |
| Use: Assess metabolic derangement as cause of altered consciousness |
| Test name: JC Virus by PCR |
| ARUP #: 0099169 |
| Methodology: Qualitative Polymerase Chain Reaction |
| Use: Aid in diagnosis of JCV |