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Basic testing for pancreatic neuroendocrine tumors (PNETs) – chromogranin A, synaptophysin, cytokeratin, Ki-67 (Mib-1), neuron specific enolase polyclonal, pan cytokeratin (AE1,3), protein gene product 9.5
Glucagonomas are pancreatic neuroendocrine tumors (PNETs) that produce excessive amounts of glucagon and are associated with a distinctive clinical syndrome. These tumors have a very high malignant potential, and are the third most common functional neuroendocrine tumor.
Tests generally appear in the order most useful for common clinical situations
| Test name: Glucagon |
| ARUP #: 0099165 |
| Methodology: Quantitative Radioimmunoassay |
| Use: Aids in diagnosis of glucagonoma |
| Test name: CBC with Platelet Count and Automated Differential |
| ARUP #: 0040003 |
| Methodology: Automated Cell Count/Differential |
| Use: Nonspecific testing in glucagonoma evaluation |
| Test name: Chromogranin A by Immunohistochemistry |
| ARUP #: 2003830 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |
| Test name: Ki-67 with Interpretation by Immunohistochemistry |
| ARUP #: 2007182 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and resulted by ARUP |
| Test name: Synaptophysin by Immunohistochemistry |
| ARUP #: 2004139 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |
| Test name: Neuron Specific Enolase, Polyclonal (NSE P) by Immunohistochemistry |
| ARUP #: 2004052 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |
| Test name: Pan Cytokeratin (AE1,3) by Immunohistochemistry |
| ARUP #: 2003433 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |
| Test name: Protein Gene Product (PGP) 9.5 by Immunohistochemistry |
| ARUP #: 2004091 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |
| Test name: Glucagon by Immunohistochemistry |
| ARUP #: 2003902 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of PNETs Stained and returned to client pathologist; consultation available if needed |