Disseminated intravascular coagulation (DIC) is a disorder characterized by massive systemic activation of coagulation with consumption of platelets and coagulation proteins.
Tests generally appear in the order most useful for common clinical situations
| Test name: CBC with Platelet Count |
| ARUP #: 0040002 |
| Methodology: Automated Cell Count |
| Use: Screen for coagulation disorder; order along with PT, PTT, TT, and fibrinogen |
| Limitations: Normal result does not rule out DIC |
| Test name: Prothrombin Time |
| ARUP #: 0030215 |
| Methodology: Electromagnetic Mechanical Clot Detection |
| Use: Screen for coagulation disorder; order along with CBC, PTT, TT, and fibrinogen |
| Limitations: Normal result does not rule out DIC |
| Test name: Partial Thromboplastin Time |
| ARUP #: 0030235 |
| Methodology: Electromagnetic Mechanical Clot Detection |
| Use: Screen for coagulation disorder; order along with CBC, PT, TT, and fibrinogen |
| Limitations: Normal result does not rule out DIC |
| Test name: Thrombin Time with Reflex to Thrombin Time 1:1 Mix |
| ARUP #: 0030260 |
| Methodology: Clotting |
| Use: Screen for coagulation disorder; order along with CBC, PT, PTT, and fibrinogen |
| Limitations: Normal result does not rule out DIC |
| Test name: Fibrinogen |
| ARUP #: 0030130 |
| Methodology: Electromagnetic Mechanical Clot Detection |
| Use: Screen for coagulation disorder; order along with CBC, PTT, and TT |
| Limitations: Normal result does not rule out DIC |
| Test name: D-Dimer |
| ARUP #: 0030057 |
| Methodology: Immunoturbidimetric |
| Use: Aid to diagnose DIC |
| Limitations: Presence of rheumatoid factor, pregnancy, acute thrombosis may lead to false-positive results |
| Test name: Soluble Fibrin Monomer |
| ARUP #: 0030126 |
| Methodology: Qualitative Hemagglutination |
| Comments: Not recommended; order d-dimer test instead |
| Test name: Inhibitor Assay, PT with Reflex to PT 1:1 Mix |
| ARUP #: 2003260 |
| Methodology: Electromagnetic Mechanical Clot Detection |
| Comments: |
| Test name: Inhibitor Assay, PTT with Reflex to PTT 1:1 Mix, with Reflex to 1-Hour Incubation |
| ARUP #: 2003266 |
| Methodology: Electromagnetic Mechanical Clot Detection |
| Comments: |
| Test name: Fibrinogen Panel |
| ARUP #: 0030137 |
| Methodology: Refer to individual components |
| Comments: |