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Central nervous system (CNS) tumors cause either focal or generalized neurologic symptoms.
Epidemiology
Risk Factors
Clinical Presentation
Specific tumors
Indications for Testing
Laboratory Testing
Histology
Imaging Studies
Prognosis
Differential Diagnosis
Tests generally appear in the order most useful for common clinical situations
| Test name: Ki-67 Tissue Assay, Paraffin |
| ARUP #: 0049270 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and resulted by ARUP |
| Test name: Glial Fibrillary Acidic Protein (GFAP) by Immunohistochemistry |
| ARUP #: 2003899 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: S-100 Protein by Immunohistochemistry |
| ARUP #: 2004127 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: CD56 (NCAM) by Immunohistochemistry |
| ARUP #: 2003589 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: p53 Tissue Assay, Paraffin |
| ARUP #: 0049250 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and resulted by ARUP |
| Test name: CD117 (c-Kit) by Immunohistochemistry |
| ARUP #: 2003806 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry |
| ARUP #: 2004097 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Human Chorionic Gonadotropin (Beta-hCG) by Immunohistochemistry |
| ARUP #: 2003920 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Alpha-1-Fetoprotein (AFP) by Immunohistochemistry |
| ARUP #: 2003436 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Inhibin by Immunohistochemistry |
| ARUP #: 2003969 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: D2-40 by Immunohistochemistry |
| ARUP #: 2003857 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: Synaptophysin by Immunohistochemistry |
| ARUP #: 2004139 |
| Methodology: Immunohistochemistry |
| Use: Aid in diagnosing CNS tumor Stained and returned to client pathologist for interpretation; consultation available if needed |
| Test name: 1p/19q Deletion by FISH |
| ARUP #: 0049360 |
| Methodology: Fluorescence in situ Hybridization |
| Use: Prognosis of oligodendrogliomas Fix in formalin for optimal results |
| Limitations: Absence of combined loss of 1p and 19q does not exclude diagnosis of oligodendroglioma |
| Test name: HNPCC/Lynch Syndrome (MLH1) Sequencing and Deletion/Duplication |
| ARUP #: 0051650 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation Probe Amplification |
| Comments: Use for Turcot and constitutional mismatch repair deficiency Identify mutations and large deletions in MLH1 gene |
| Test name: HNPCC/Lynch Syndrome (MSH2) Sequencing and Deletion/Duplication |
| ARUP #: 0051654 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation Probe Amplification |
| Comments: Use for Turcot and constitutional mismatch repair deficiency Detect mutations and large deletions in MSH2 gene |
| Test name: HNPCC/Lynch Syndrome (MSH6) Sequencing and Deletion/Duplication |
| ARUP #: 0051656 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation Probe Amplification |
| Comments: Use for Turcot and constitutional mismatch repair deficiency Detect mutations and large deletions in MSH6 gene |
| Test name: HNPCC/Lynch Syndrome (PMS2) Sequencing and Deletion/Duplication |
| ARUP #: 0051737 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation-dependent Probe Amplification |
| Comments: Use for Turcot and constitutional mismatch repair deficiency Detect mutations and large deletions in PMS2 gene Suspected deletions or duplications in exons 12-15 require additional sequencing to exclude pseudogene copy number variants |
| Test name: PTEN-Related Disorders (PTEN) Sequencing and Deletion/Duplication |
| ARUP #: 2002470 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation-dependent Probe Amplification |
| Comments: |
| Test name: von Hippel-Lindau (VHL) Deletion/Duplication |
| ARUP #: 2002988 |
| Methodology: Polymerase Chain Reaction/Multiplex Ligation-dependent Probe Amplification |
| Comments: |
| Test name: von Hippel-Lindau (VHL) Sequencing |
| ARUP #: 2002970 |
| Methodology: Polymerase Chain Reaction/Sequencing |
| Comments: |
| Test name: von Hippel-Lindau (VHL) Sequencing and Deletion/Duplication |
| ARUP #: 2002965 |
| Methodology: Polymerase Chain Reaction/Sequencing/Multiplex Ligation-dependent Probe Amplification |
| Comments: |