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Anaphylaxis is an acute, potentially fatal allergic reaction that is most often IgE-mediated and can involve multiple organ systems.
Tests generally appear in the order most useful for common clinical situations
| Test name: Immunoglobulin E |
| ARUP #: 0050345 |
| Methodology: Quantitative Electrochemiluminescent Immunoassay |
| Use: May be useful in evaluation of allergic disease including therapies for asthma |
| Limitations: May also be elevated in AML, MDS, mastocytosis, hypereosinophilic syndrome |
| Test name: Tryptase |
| ARUP #: 0099173 |
| Methodology: Quantitative Fluorescence Immunoassay |
| Use: May be useful in confirming anaphylaxis |
| Limitations: Measures total tryptase; does not distinguish between alpha and beta protein types |
| Test name: Tryptase, Mature and Total by ELISA |
| ARUP #: 2005771 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: May be useful in confirming anaphylaxis |
| Test name: Histamine, Whole Blood |
| ARUP #: 0070037 |
| Methodology: Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: May be useful in confirming anaphylaxis |
| Limitations: Sample must be drawn near time of event |
| Test name: Histamine, Plasma |
| ARUP #: 0070036 |
| Methodology: Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: May be useful in confirming anaphylaxis |
| Limitations: Sample must be drawn near time of event |
| Test name: Histamine, Urine |
| ARUP #: 0070038 |
| Methodology: Quantitative Enzyme Immunoassay |
| Use: May be useful in confirming anaphylaxis May be more useful than serum measures, but negative test does not rule out anaphylaxis |
| Limitations: Sample must be drawn near time of event |