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Anaphylaxis is an acute, potentially fatal hypersensitivity reaction that is most often IgE-mediated and can involve multiple organ systems.
Tests generally appear in the order most useful for common clinical situations
| Test name: Immunoglobulin E |
| ARUP #: 0050345 |
| Methodology: Quantitative ImmunoCAP® Fluorescent Enzyme Immunoassay |
| Use: May be useful in evaluation of allergic disease |
| Limitations: May also be elevated in AML, MDS, mastocytosis, hypereosinophilic syndrome |
| Test name: Tryptase |
| ARUP #: 0099173 |
| Methodology: Quantitative Fluorescent Enzyme Immunoassay |
| Use: May be useful in confirming anaphylaxis; generally not used acutely except where diagnosis is unclear |
| Limitations: Sample must be drawn near time of event (within 3 hrs of symptom onset) Measures total tryptase; does not distinguish between alpha and beta protein types |
| Test name: Histamine, Whole Blood |
| ARUP #: 0070037 |
| Methodology: Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: May be useful in confirming anaphylaxis |
| Limitations: Sample must be drawn near time of event |
| Test name: Histamine, Plasma |
| ARUP #: 0070036 |
| Methodology: Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: May be useful in confirming anaphylaxis |
| Limitations: Sample must be drawn near time of event |
| Test name: Histamine, Urine |
| ARUP #: 0070038 |
| Methodology: Quantitative Enzyme Immunoassay |
| Use: May be useful in confirming anaphylaxis May be more useful than serum measures, but negative test does not rule out anaphylaxis |