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Adenoviruses usually cause mild, self-limiting respiratory illnesses, primarily in children.
Tests generally appear in the order most useful for common clinical situations
| Test name: Respiratory Viruses DFA with Reflex to Viral Culture |
| ARUP #: 0060281 |
| Methodology: Direct Fluorescent Antibody Stain |
| Use: Rapid test to identify common agents in respiratory infections; if negative, reflexes to viral culture Tests for adenovirus, influenza A and B, parainfluenza, respiratory syncytial virus, and human papillomavirus |
| Test name: Respiratory Viruses Rapid Culture |
| ARUP #: 2001504 |
| Methodology: Cell Culture/Immunofluorescence |
| Use: Respiratory viruses that can be isolated include influenza A and B, parainfluenza types 1, 2, 3, adenovirus, and RSV |
| Limitations: Other viruses such as HSV, CMV or human metapneumovirus not routinely detected in this culture Test has decreased sensitivity for detection of adenovirus compared to conventional culture |
| Test name: Adenovirus DNA, Qualitative, RT-PCR |
| ARUP #: 2002088 |
| Methodology: Real-Time Polymerase Chain Reaction |
| Use: Detect adenovirus Highly sensitive and specific |
| Limitations: Not a rapid test but fewer false negatives than DFA |
| Test name: Adenovirus 40-41 Antigens by EIA |
| ARUP #: 0065066 |
| Methodology: Qualitative Enzyme Immunoassay |
| Use: Confirm etiologic agent of gastroenteritis |
| Test name: Adenovirus Antibodies, IgG & IgM |
| ARUP #: 0051077 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Use: Useful in epidemiological studies |
| Limitations: Requires acute and convalescent paired sera |
| Follow-up: For equivocal values, repeat testing in 10-14 days may be helpful |
| Test name: Adenovirus by Immunohistochemistry |
| ARUP #: 2003430 |
| Methodology: Immunohistochemistry |
| Use: Aid in histologic diagnosis of adenovirus Stained and returned to client pathologist; if consultation required, contact anatomic pathology, surgical consult or hematopathology |
| Test name: Viral Culture |
| ARUP #: 0065008 |
| Methodology: Cell Culture |
| Use: Use to identify agent in the following diseases:
Slow growth - not ideal for acute identification |
| Test name: Adenovirus Antibody, IgG |
| ARUP #: 0051073 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Comments: Useful in epidemiological studies |
| Test name: Adenovirus Antibody, IgM |
| ARUP #: 0051078 |
| Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay |
| Comments: Useful in epidemiological studies |
| Test name: Respiratory Viruses DFA |
| ARUP #: 0060289 |
| Methodology: Direct Fluorescent Antibody Stain |
| Comments: Low sensitivity compared to culture; culture or PCR backup recommended to rule out diagnosis |
| Test name: Rotavirus & Adenovirus 40-41 Antigens |
| ARUP #: 0065067 |
| Methodology: Qualitative Enzyme Immunoassay |
| Comments: |